
Entanglement : Cancer and Sun Tzu Art of War / Yi Jing. Sun Tzu Bing Fa = Sun Tzu's Art of War ( purportedly the Deadliest Strategy of Warfare in existence. ) Mr. Lee Hsien Loong, Mdm. Ho Ching and Mr. Lee Kuan Yew , I trust that as your Sun Tzu Bing Fa militants in Singapore and Malaysia and elsewhere around the world are savouring their metastatic CANCER afflictions in bed, these long-awaited genetic lotteries will be infusing itself into your goodselves gently. Yea, by the way, may Mr. Kim Jong il blesses you with his thermonuclear Firecrackers right in your turf. May Elohei Yisrael levy per heartbeat a 1 modern Shekel cost for the proper cellular automation processes in each and every cell in your glorious bodies. Welcome to the era of Levantine comminution of Reality. Ad Majorem Elohei Yisrael Gloriam. Ahava Rabah, Shrek Ha Gadol.Mahshabah ke-ma'aseh: "Thought is like Act (YHWH takes the will for the deed)" Gene amplification : a cellular process characterized by the production of multiple copies of a particular gene or genes to amplify the phenotype that the gene confers on the cell. Drug resistance in cancer cells is linked to gene amplification that prevents absorption of the chemo-therapeutic agent by the cancerous cell. The almost universal genetic codon dictionary has a "Degenerate Code" where similar codons produce the same type of amino acids. You are not called to be a Kabbalistic Sorcerer but a middle-Eastern thinking Evangelist !

Gradients (ATP Synthases) NDSU Virtual Cell Animations Project animation 'Gradients (ATP Synthase)'. For more information please see vcell.ndsu.edu Gradients are used to create energy that can power biological cyles. ATP synthase is powered by a hydrogen gradient, located in the mitochondria. This section covers the action of this specific gradient.

Biochem fun Presentation of Carbamoyl-phosphate Synthetase Type I.

Glutamyl-tRNA synthetase inhibition

"Long Polypeptide Chain" To the song "Long Shadow" by Joe Strummer. AP Biology Extra Credit Well I'll tell you one thing that I know You don't get your protein for free Theres a whole lotta work to get those vital things Step one's transcription, and its alright It happens in the nucleus that place of might DNA acts as a template for mRNA synthesis The helix unwinds from 5' to 3 til we get whats important And If we put it all together And everything runs real smooth You know we'll get a protein For our cells to use When transcription ends, step 2 begins They call it translation Its somewhat intricate so pay attention mRNA is translated into a polypetide chain but this couldn't happen w/o tRNA it carries an amino acid and anticodons too when one reaches the mRNA held by the ribosome it knows just what to do the A and P and E sites cradle the tRNA when the anticodons find a match, the amino acids added to the chain and if we put it all together and everything runs real smooth you know we'll get a protein for our cells to use what happens in between? mRNA is changed No introns and added A 5' cap and a poly-A tail What of the others? Those who did help out They're as important, so whats this all about? RNA polymerase—to the promoter it binds And during transcription, when it does its job, the DNA unwinds Transcription factors are proteins that give polymerase the go-ahead And aminoacyl-tRNA synthetase provides a tRNA with its head And if you put it all together You get a protein that's real grand Our ...

Citric Acid Cycle II This course is part of a series taught by Kevin Ahern at Oregon State University on General Biochemistry. For more information about online courses go to ecampus.oregonstate.edu 1. The citric acid cycle consists of two main parts - release of CO2 (first part) and conversion to oxaloacetate (second part). You are responsible for the structures of molecules in the citric acid cycle and the names of the enzymes. 2. In the "first" reaction of the citric acid cycle, citrate synthase catalyzes the joining of the acetyl group from acetyl-CoA to oxaloacetate to make citrate. This reaction is VERY energetically favorable, due to breaking of the thioester bond in acetyl-CoA. The energetically favorable reaction helps to "pull" the relatively unfavorable reaction preceding it. 3. Aconitase catalyzes the rearrangement of citrate to isocitrate. For your information - Aconitase is inhibited by fluorocitrate. Fluoroacetate is a poison that can be used by citrate synthase to make fluorocitrate. 4. The first decarboxylation of the citric acid cycle is catalyzed by isocitrate dehydrogenase and the reaction is strongly favored to the right. The products of this reaction are NADH and alpha ketoglutarate. 5. Alpha ketoglutarate is an important intermediate for its involvement in anapl*** reactions related to transamination (we'll talk about these later). The mechanism of the enzyme acting on alpha ketoglutarate (alpha ketoglutarate dehydrogenase complex) is virtually identical to the ...

ATP Synthase An amazing molecular machine, ATP synthase, can run use electrostatic potential energy stored in a proton gradient to generate ATP. Under different conditions, it can run in the opposite direction, using ATP to build a proton gradient. Created by Graham Johnson of and Graham Johnson medical media , for Molecular Biology of the Cell, 4e by Alberts, Walter, et al, Gardland Publishers. ©2002 Please visit for examples of other molecular machines.

Retinal Microvasculature by 3D Confocal Microscopy Immunofluorescence imaged with a Zeiss LSM510 Meta confocal microscope. C57/BL6 mouse eye cups were incubated with Mouse monoclonal anti-Glutamine Synthetase (Chemicon, MAB302) to detect Muller Cells and visualized using donkey anti-mouse IgG Alexafluor 488 (Invitrogen, A21202). Vascular endothelial cells were detected using Isolectin B4, Griffonia simplicifolia, conjugated with Alexafluor 568 (Invitrogen, I21412). Nuclei were probed using Hoechst 33258. Following immunolabeling, tissue was embedded in Epon-araldite expoxy, faced with a Leica RM 2165 microtome, and floated on a 40x/NA1.4 oil immersion objective. Rotating 3D retinas are oriented so that the vitreal surface is down.

IanB2001 says a word with more than 1000 letters The word is Methionylglutaminylarginytyrosylglutamylserylleucylphenylalanylalanylglutaminyll-eucyllysylglutamylarginyllysylglutamylglycylalanylphenylalanyvalylprolylphenylalanyl-valythreonylleucylglycylaspartylprolyglycylisoleucylglutamylglutaminylserylleucyllysyl-isoleucylaspartylthreonylleucylisoleucylglutamylalanylglycylalanylaspartylalanylleucy-lglutamylleucylglycylglycylisoleucylprolylphenylalanylserylaspartylprolylleucelalanyla-spartyglycylprolythreonylisoleucylglutamiylasparaginylalanylthreonylleucylarginylala-nylphenylalanylalanylglycylvalyltheonylprolylalanylglutaminylcysteinylphenylalanygll-utamylmethionylleucyalanylleucylisoleucylarginylglutaminyllysylhistidylprolylthreonyl-isoleucylpriIylisoleucylglycylleucylleucylmethionyltyrosylalanylasparaginylleucylvalyp-henylalanylasparaginyllysylgyycylisoleucylaspartylglutamylphenylalanyltyrosylalanyl-gutaminyllcysteinylglutamyllysylvalylglycylavlylaspartylserylvalylleucylvalylalanylasp-artylvalyprolylvalylglutaminylglutamyllserylalanyprolyphenylalanylarginylglutaminylal-anylalanylleucylarginylhistidylasparaginylvaylalanylprolylisoleucylphenylalanylisoleu-cylcysteinylprolylprolylaspartylalanylaspartylaspartylaspartylleucylleucylarginyglutam-inylisoleucylalanyylseryltyrosylglycylarginylglycyltyrosylthreonyltyrosylleucylleucylser-ylarginylalanylglycylvalythreonylglycylalanylglutamylasparaginylarginylanylalanylleu-cylprolylleucylaspaaginylhistidylleucylvaylalanyllysylleucyllysylglutamyltyrosylasarag ...

ATP Synthétase

Longest Chemical Names Of 2007 LONG WORDS - CHEMICAL NAMES Shown below is a 1185-letter chemical term for "Tobacco Mosaic Virus, Dahlemense Stain." This word has appeared in the American Chemical Society's Chemical Abstracts and is considered by some to be the longest real word. ACETYLSERYLTYROSYLSERYLISOLEUCYL- THREONYLSERYLPROLYLSERYLGLUTAMINYL- PHENYLALANYLVALYLPHENYLALANYLLEUCYL- SERYLSERYLVALYLTRYPTOPHYLALANYL- ASPARTYLPROLYLISOLEUCYLGLUTAMYLLEUCYL- LEUCYLASPARAGINYLVALYLCYSTEINYL- THREONYLSERYLSERYLLEUCYLGLYCYL- ASPARAGINYLGLUTAMINYLPHENYLALANYL- GLUTAMINYLTHREONYLGLUTAMINYLGLUTAMINYL- ALANYLARGINYLTHREONYLTHREONYL- GLUTAMINYLVALYLGLUTAMINYLGLUTAMINYL- PHENYLALANYLSERYLGLUTAMINYLVALYL- TRYPTOPHYLLYSYLPROLYLPHENYLALANYL- PROLYLGLUTAMINYLSERYLTHREONYLVALYL- ARGINYLPHENYLALANYLPROLYLGLYCYL- ASPARTYLVALYLTYROSYLLYSYLVALYLTYROSYL- ARGINYLTYROSYLASPARAGINYLALANYLVALYL- LEUCYLASPARTYLPROLYLLEUCYLISOLEUCYL- THREONYLALANYLLEUCYLLEUCYLGLYCYL- THREONYLPHENYLALANYLASPARTYLTHREONYL- ARGINYLASPARAGINYLARGINYLISOLEUCYL- ISOLEUCYLGLUTAMYLVALYLGLUTAMYL- ASPARAGINYLGLUTAMINYLGLUTAMINYLSERYL- PROLYLTHREONYLTHREONYLALANYLGLUTAMYL- THREONYLLEUCYLASPARTYLALANYLTHREONYL- ARGINYLARGINYLVALYLASPARTYLASPARTYL- ALANYLTHREONYLVALYLALANYLISOLEUCYL- ARGINYLSERYLALANYLASPARAGINYLISOLEUCYL- ASPARAGINYLLEUCYLVALYLASPARAGINYL- GLUTAMYLLEUCYLVALYLARGINYLGLYCYL- THREONYLGLYCYLLEUCYLTYROSYLASPARAGINYL- GLUTAMINYLASPARAGINYLTHREONYL- PHENYLALANYLGLUTAMYLSERYLMETHIONYL- SERYLGLYCYLLEUCYLVALYLTRYPTOPHYL ...

From Structure and Function of Ribosomes to New Antibiotics Sterling Professor of Molecular Biophysics and Biochemistry, HHMI Investigator, and recipient of the 2009 Nobel Prize for Chemistry Thomas A. Steitz, Ph.D., gives his Nobel Lecture, which he first delivered at Stockholm University on December 8, two days before receiving the Nobel Prize from Swedens King Carl XVI Gustaf.

di6hr8k The structoric brillog and parenthetic synthetase.

Re: Longest Word Saying Pneumonoultramicroscopicsilicovolcanoconiosis Backwards. Then saying Methionylglutaminylarginyltyrosylglutamylserylleucylphen- ylalanylalanylglutaminylleucyllysylglutamylarginyllysylgluta- mylglysylalanylphenylalanylvalylprolylphenylalanylyalylthre- onylleucylglcycylaspartylprolylglicylisoleucyglutamylgluta- minlserylleucyllysylisoleucylaspartylthreonylleucylisoleu- cylglutamylalanylglyclyalanylaspartylalanylleucyglutamylle- ucylgluycylisoleucylproluylphenylalanyserylaspartyprolylleu- celalanylaspartylglycylprolylthreonylisolleucyglutaminylaspa- raginylalanythreonylleucylarginylalanylphenylalanylalanylal- anylglycylvalylthreonylprolylalanylglutaminylcysteinylphen- ylalanylglglutamylmethionylleucyalanylleucylisoleucylarginyl- glutaminyllysylhistidylprolyuthreonylisoleucylprolylisoleuc- ylglycylleucylleucylmethionyltyrosylalanylasbaraginylleucyl- valylphenylalanylsparaginyyllysylglycylisoleucylaspartylglut- amylphenylalanylyltyrosylalanylglutaminylcysteinylglutamyll- ysylvalylglycylvalylspartylserylvalylleucylvallalanylaspart-ylvalylprolylvalvlglutaminylglutamylserylalanylprolylpheny- lalalrginylglutaminylalanylalanylleucylarginylhistidylasp- araginylvalylalalprolylisoleucylphenylalanylisoleucylcystei- nylprolyprolylaspartylalanylaspartylaspartyspartyleucylle- ucylarginylglutaminylisoleucylalanylseryltyroslglycylargin- ylglycyltyrosylthreonyltyrosylleucylleucylserylarginlalanyl- glycylvalylthreonylglycylalanylglutamylasparaginylarginyla ...

Empire Citrate of Mind The TCA Cycle set to Jay-Z and Alicia Keys' Empire State of Mind. Done in January 2010 for Dr. Harper's Intermediary Metabolism class at University of Ottawa. Hey Rick Rubin: I'm unsigned! Lyrics: [Verse] Yeah, Hans Krebs out at Cambridge gettin' down in '37 found the Citric Acid Cycle, citrate goes 'round forever Pyruvate dehydrogenase reduces NAD (plus) By taking pyruvate, makes an acetyl-CoA Citrate Synthase ballin' condenses acetyl-CoA and oxaloacetate to regenerate citrate Aconitase rolls up, rearranges citrate to iso-citrate via f-'n cis-aconitate Flows through the next enzyme: isocitrate Dehydrogenase goes through oxalosuccinate Makes alpha-ketoglutarate and an NADH Kicks out a CO2, but now we gotta make succinyl-CoA with alpha-ketoglutarate dehydrogenase enzyme makes NADH a CO2 gets knocked out by another CoA Welcome to the halftime of the [Chorus] TCA Cycle! Amphibolic pathway inside you There's nothing you can do without TCA Cycle! It makes your energy brand new Helps cell to respire for you TCA Cycle, cycle, cycle! [Verse] Catch succinyl-CoA synthetase makin' GTP st if you ain't lost yet, here's my number tutor me Succinyl-CoA turns to CoA-less succinate unless it gettin' beef from inhibitor malonate Succinate Dehydrogenase makes FADH2 and double-bonded fumarate then hydrated to L-malate by enzyme fumarase, holla back then Malate Dehydrogenase takes the cycle to the last step Oxaloacetate with the last NADH Back to the start where it becomes citrate That's all ...

Kathryn Chepiga, Chemistry Kathryn Chepiga delivered her senior thesis, titled "Inhibition of Very Long Chain Acyl-CoA Synthetase 3 in U87 Malignant Glioma Cells: A Potential Cancer Treatment."

Upregulation of Argininosuccinate Synthetase and it's Effects on Arginine (Along with NO) production A video recorded for Biochemistry 4002 class at Memorial University. John Jeddore, Greg Morrow, George Furey, Allison Guzzwell

Protein Synthesis II This course is part of a series taught by Kevin Ahern at Oregon State University on General Biochemistry. For more information about online courses go to ecampus.oregonstate.edu 1. The anticodon loop has three bases complementary to the codon in the mRNA. tRNAs provide the translation function between nucleic acid sequence and amino acids. The anticodon loop frequently contains the inosine base. The base at the 3' end of the codon of the mRNA (corresponds to the base at the 5' end of the anticodon in the tRNA) is called the wobble base because it is less important for specifying the amino acid to be inserted than the first two bases. 2. Aminoacyl-tRNA synthetases have the ability to recognize and correct errors in joining of amino acids to tRNAs. For example, if one puts the wrong amino acid on the end of a tRNA and then adds an appropriate aminoacyl-tRNA synthetase, the amino acid is readily removed. 3. Two regions of aminoacyl-tRNA synthetases are important for editing - called the activation site and the editing site. 4. There are two classes of amino acid tRNA synthetases. They differ in the way they bind tRNAs and in which hydroxyl of the ribose ring they attach the amino acid to. Class I enzymes attach the amino acid to the hydroxyl on carbon #2. Class II enzymes attach the amino acid to the hydroxyl on carbon #3. 5. Base pairings in RNA are slightly different than in DNA. For example, GU base pairs are not unstable. "I" (inosine) can also pair with C,U, or A. 6. In ...