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  • Hyperpolarized Carbon 13 MRI for Imaging of Metabolism and Perfusion - Aaron Grant Aaron Grant, People, 2011, Open House, MRI, Boston, BIDMC, HMS
  • 011 Hyperpolarization - the end of the action potential www.interactive- - After Depolarization and Repolarization comes Hyperpolarization, where the membrane potential falls beneath the Resting Membrane Potential. Watch the video to learn more! http
  • Heart Lungs MRI Presentation of MIP and photorealistic surface mode in Ambivu workstation
  • Design Start to Finish Learn about the wide array of real-world design projects biomedical engineering students work on as UW-Madison undergraduates and the skills those students develop during the process. Projects range from monitoring patient food intake to developing innovative pill dispensers, processes to micro-encapsulate hormones or new suturing techniques. One group even measured ambient temperature in football helmets to prevent heatstroke.
  • Part 6a - Resting Membrane Potential This is Part 6a of a new series on the human nervous system. The Part 6a video will go over the basics of electricity as well as introduce the concept of a membrane potential and how this can be altered; in Part 6b we will go over the Nernst and GHK equations, as well as the Na+/K+ATPase Pump involved in resting membrane potential. See my channel for more tutorials on physiology and related subjects.
  • Neuron, Action Potential, Part 2: Depolarization, Repolarization, Hyperpolarization Neuron, Action Potential generation: Depolarization, Repolarization and Hyperpolarization. Produced for Anatomy and Physiology class at New York City College of Tehcnology, supported by NSF.
  • BME Design Story Get an up-close look at how a group of four senior biomedical engineering students develops a ventilator for a doctor in the medical physics department.
  • Social Media, Government & 21st Century eDemocracy Host Alex Howard of O'Reilly Radar moderates a panel including Clay Johnson, Lorelei Kelly, and Matt Lira in a February 17, 2012 discussion on the meaningful use of social media by Congress and the Government as part of Social Media Week DC.
  • The face of a frog Time-lapse video reveals never-before-seen bioelectric pattern This video shows time-lapse images of the "electric face" -- dynamic patterns of membrane voltage visible on the surface of the developing frog embryo. Credit: Dany S. Adams, Ph.D., research associate professor in the Department of Biology in the Tufts School of Arts and Sciences and a member of the Tufts Center for Regenerative and Developmental Biology; Laura N. Vandenberg, Ph.D., post doctoral associate in the Department of Biology in the Tufts School of Arts and Sciences For the first time, Tufts University biologists have reported that bioelectrical signals are necessary for normal head and facial formation in an organism and have captured that process in a time-lapse video that reveals never-before-seen patterns of visible bioelectrical signals outlining where eyes, nose, mouth, and other features will appear in an embryonic tadpole. The Tufts research with accompanying video and photographs will appear July 18 online in advance of publication in the journal Developmental Dynamics. The Tufts biologists found that, before the face of a tadpole develops, bioelectrical signals (ion flux) cause groups of cells to form patterns marked by different membrane voltage and pH levels. When stained with a reporter dye, hyperpolarized (negatively charged) areas shine brightly, while other areas appear darker, creating an "electric face." "When a frog embryo is just developing, before it gets a face, a pattern for that face lights up on the surface of the embryo ...
  • Somatic Nervous System and Special Senses - 2 of 5 -- RL216 Human Anatomy and Physiology Somatic Nervous System and Special Senses -- Part 2 of 5
  • Biology 1A - Lecture 38: Summation General Biology Lecture
  • Oh Na+ Na+ Oh na na, what's my name? Sodium Oh na na, what's my name? Sodium Oh na na, what's my name? What's my name, what's my name? Sodium I heard you good with those sodium-potassium channels Yeah, you know those action potentials The threshold's at -55mV something, right 'cause I've been tryna fire my AP, oooow full fire or not at all it's the all or none principle Okay, here we go First thing we have on is sodium channel Oh, flood on in, membrane becomes more positive With depolarization You're just waiting till it hits past +50mV That's when the sodium channels close K ion channels open, potassium We're gonna go through something called repolarization That's when the action potentials stop Absolute refractory period where the Potassium flows out Okay, now all the channels are closed In the relative refractory period to a Hyperpolarized membrane potential
  • The Retinal Layers & Phototransduction Review of the tri-layer retina and conversion of light to a neural signal.
  • 035 On Center, Off Surround Ganglion Cells www.interactive- - In this episode, I go into detail about how On Center, Off surround Ganglion cells respond to light that stimulates rods and cones in the center and the surround of the ganglion cell's receptive fields.
  • Insidermedicine in 60 - November 28, 2007 From Philadelphia - A new test shows that exposure to second hand smoke can affect alveoli in the lungs. Researchers evaluated the lungs of smokers, non-smokers who had limited exposure to cigarettes and non-smokers who were exposed to second-hand smoke, using hyperpolarized helium diffusion MRI. Lung changes that are typically seen in smokers were seen in nearly a third of those who were exposed to second hand smoke, even though they didn't have symptoms. From Providence - A hospital has been fined $50000 for its third wrong site surgery this year. The latest incident involved a resident starting a burr hole on the wrong side of a patient's head. Luckily, the mistake was noted prior to drilling into the skull and the correct side was ultimately operated upon. And finally, from Kingston - What do you get when you have the Canadian Medical Association, representatives from Government, and prominent health critics in the same room? The announcement of 5 new priority areas for wait times in Canada. With significant progress made in previous areas like cataract and hip surgery, the new areas of interest include emergency room visits, infections and mental health. For Insidermedicine in 60, I'm Dr. Susan Sharma.
  • 013 A Review of the Action Potential www.interactive- - Depolarization, repolarization, hyperpolarization - It's all here. Watch this for a review of the action potential. http
  • Potassium Homeostasis: Part 1 A freshman/sophomore pre-nursing discussion on how the body maintains homeostasis of potassium. Topics discussed include why potassium is important, what are the names for deviations of concentration below and above homeostatic levels, causes of those deviations, effects of those deviations, and how the major methods the body uses to correct those deviations. A copy of this diagram can be found at
  • Bipolar Cells (Vision 2 of 5) - The second video in the Vision series. This tutorial explores the bipolar cells of the retina and looks at their interaction with photoreceptors. For more entirely FREE tutorials and accompanying PDFs visit http
  • Hyperpolarized-gas MRI of the lung: Can research potential translate to clinical application? Presented at SPIE Medical Imaging 2012 - Dr. John Mugler III Univ. of Virginia (USA) The exceptionally-high magnetic-reso- nance signal provided by hyperpolarized noble gases, such as helium-3 and xe- non-129, permits direct, high-resolution MRI of the airspaces of the lung. Combining this high signal with the inherent flexibility of MRI has resulted in an arsenal of techniques that offer a wealth of regional information on the functional status and structure of the healthy and diseased lung. No other medical-imaging modality can provide comparable information about the lung, which is of particular relevance considering the growing need to address the global impact of pulmonary diseases, such as asthma and chronic obstructive pulmonary disease, on health and quality of life. Despite this impressive and unique potential, which has been amply demonstrated through a wide-range of research studies in animals and humans, hyper- polarized-gas MRI has yet to translate to a clinical imaging tool. Although an outside observer of the field may conclude that lack of translation means lack of sufficient added-value to the evaluation of pulmonary diseases, the true reason is rooted in practical and technical issues, not ultimate potential. On the practi- cal side, commercial and patent issues have blocked widespread dissemination of hyperpolarized-gas technology since the late 1990s. On the technical side, improved image-***ysis approaches are needed to distill imaging ...
  • Sour Face Sour taste is detected by a small subset of cells that are distributed across all taste buds in the tongue. Sour taste cells can be identified by expression of the protein PKD2L1,[32] although surprisingly this gene is not required for sour responses. There is evidence that the protons that are abundant in sour substances can directly enter the sour taste cells. This transfer of positive charge into the cell can itself trigger an electrical response. It has also been proposed that weak acids such as acetic acid, which are not fully dissociated at physiological pH values, can penetrate taste cells and thereby elicit an electrical response. According to this mechanism, intracellular hydrogen ions inhibit potassium channels, which normally function to hyperpolarize the cell. By a combination of direct intake of hydrogen ions (which itself depolarizes the cell) and the inhibition of the hyperpolarizing channel, sourness causes the taste cell to fire action potentials and release neurotransmitter. The mechanism by which animals detect sour is still not completely understood.