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hypercellular

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Images

  • bone marrow showing a hypercellular marrow with an epithelioid granuloma arrow Hematoxylin and eosin stain Quallich et al BMC Gastroenterology 2001 1 8 doi 10 1186 1471 230X 1 8 Download authors original image
  • peripheral blood smear shows slightly decreased WBCs with no evidence of CML bone marrow biopsy is slightly hypercellular with normal megakaryocytes and slight erythroid hyperplasia high power shows reduced granulocytes and slight erythroid hyperplasia interstitium shows cellular depletion with loosely arranged cells Positive stains myeloperoxidase specific
  • 3 4 5 6 markedly hypercellular marrow 1 with granulocytes and clusters of megakaryocytes 2 with numerous markedly distorted megakaryocytes 3 with granulocytes in all stages of maturation and
  • The four main myeloproliferative disorders share several similarities such as a hypercellular marrow a high white count with a left shift and splenomegaly But there are distinct
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  • clusters of large platelets platelet count is 1700K various images bone marrow biopsy increased megakaryocytes 1 2 many megakaryocytes are unusually large 3 4 in mildly hypercellular marrow of 66 year old woman with platelet count of 1200K bone marrow smear
  • 3 decreased iron stores refractory anemia with ringed sideroblasts 1 2 figure 1 bone marrow aspirate shows mild increase in plasma cells and mast cells 2 hypercellular marrow with increase in erythroid precursors adjacent to trabeculae 3 iron stain
  • bone marrow biopsy increased megakaryocytes 1 2 many megakaryocytes are unusually large 3 4 in mildly hypercellular marrow of 66 year old woman with platelet count of 1200K bone marrow smear increased megakaryocytes 1 2
  • corresponds to softest components like fat yellow and green to intermediate components and blue to the hardest components like hypercellular lesions or those with an intense fibrosis Figure 1 16 The proposed elasticity classification included four scores corresponding to the colors variation during compression and after decompression of the area of interest Score
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  • The bone marrow aspirate smear was dilute and hypocellular and suboptimal for evaluation However the biopsy was hypercellular 95 cellular and was composed almost entirely of
  • blood monocyte counts in addition to bone marrow aspirate and biopsy Fig 8 Cytogenetics as well as RT PCR for bcr abl fusion should be performed to rule out CML
  • 2 megakaryocytes are often small with hypolobulated nuclei post interferon 54 year old man peripheral blood smear shows slightly decreased WBCs with no evidence of CML bone marrow biopsy is slightly hypercellular with normal megakaryocytes and slight erythroid hyperplasia high power shows reduced granulocytes and slight erythroid hyperplasia interstitium
  • 5 6 chronic phase bone marrow biopsy hypercellular marrow with panmyeloid hyperplasia and moderate adipocytes hypercellular marrow with increased megakaryocytes 1 2 3 showing primarily neutrophils
  • neutrophil with pseudo Pelger Huet nucleus 33 year old man with knee pain peripheral blood shows 47 basophils 10 blasts t 9 22 present accelerated phase bone marrow biopsy moderately hypercellular bone marrow biopsy with numerous megakaryocytes 1 2 some megakaryocytes are micromegakaryocytes with hypolobulated nuclei moderate increase in reticulin fibers
  • tan fluid admixed with necrotic debris Microscopically the viable portion of the tumor had alternating hypercellular and hypocellular areas as well as focal areas of coagulative necrosis Fig 1 Individual tumor cells varied greatly Fig 2 and included small spindle shaped cells larger strap like cells with abundant pink eosinophilic cytoplasm
  • in the hypercellular regions Neither atypical mitotic figures nor bizarre nuclear pleomorphism were seen Of interest were the large rosette like structures with hyalinized centers Figs 2a 5 Diagnosis Low Grade Fibromyxoid Sarcoma With Hyalinizing Giant Rosettes Timothy R Smith MS3 and Donald R Chase MD
  • of a hypercellular proliferation of atypical spindle cells some with vacuolated cytoplasm Much of the tumor had a myxoid appearance with scattered capillary sized stellate blood vessels Figs 3 4 Mitotic figures were variable ranging from 0 to 5 per 10 hpf and occasional atypical forms were seen Areas of transition from hypo to hypercellular regions were seen Fig 5
  • adrenal gland 1 2 thyroglobulin stain 3 TTF1 stain lingual thyroid 1 H E and thyroglobulin 2 ectopic thyroid tissue is beneath squamous epithelium of tongue has hypercellular and microfollicular appearance that may cause mistaken diagnosis of malignancy radioiodine scan showed no
  • nuclei also ringed sideroblasts <15 occasional dysplastic neutrophils no increase in myeloblasts 6 year old girl with trisomy 8 severe anemia and 1 2 blasts in peripheral blood hypercellular marrow with marked fibrosis increased megakaryocytes singly and in clusters and scattered erythroid islands cluster of large megakaryocytes with abnormal nuclear lobulation
  • 5a Microscopically hypercellular areas of spindle shaped cells with nuclear palisading Antony A pattern hematoxylin eosin stain original magnification x 100 Figure 5b Microscopically hypocellular areas of spindle shaped cells loose lacking arrangement in bundles and pallisading Antony B pattern hematoxylin
  • Bone Marrow Core Biopsy Examination of the Hematoxylin and Eosin stained sections of the bone marrow biopsy Figure 3 shows a hypercellular marrow 70 90 with interstitial to diffuse involvement by small cytologically low grade lymphocytes Trilineage hematopoiesis is patchy with moderately
  • Myeloid and megakaryocytic elements are often increased in the bone marrow Fig 1 More than 60 of patients will have endogenous megakaryocyte colony unit formation
  • trisomy 8 severe anemia and 1 2 blasts in peripheral blood hypercellular marrow with marked fibrosis increased megakaryocytes singly and in clusters and scattered erythroid islands cluster of large megakaryocytes with abnormal nuclear lobulation and adjacent erythroid precursors bone marrow biopsy post allogeneic bone marrow transplant shows marked reduction in
  • Hypercellular marrow composed of medium sized atypical lymphs Hemophagocytosis Immunophenotype
  • Hypercellular follicular proliferation of medium size elements fig A filled with abundant colloid
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  • 4 Irradiated thyroid gland An irradiated thyroid gland containing a hypercellular nodule consisting almost entirely of microfollicles and showing focal nuclear atypia
  • mild to moderate anisopoikilocytosis 2 with blast micromegakaryocyte and hypolobulated neutrophil bone marrow biopsy markedly hypercellular marrow with prominent megakaryocytes 1 2 3 4 patients with JAK2 exon 12 mutations
  • hypercellular regions Neither atypical mitotic figures nor bizarre nuclear pleomorphism were seen Of interest were the large rosette like structures with hyalinized centers Figs 2a 5 Diagnosis Low Grade Fibromyxoid Sarcoma With Hyalinizing Giant Rosettes Timothy R Smith MS3 and Donald R Chase MD Department of Pathology and Human Anatomy
  • firm with areas of softening Histological examination revealed a spindle celled proliferation with nuclear palisading and veruocay body formation confirmed the diagnosis fig 5 Figure 5a Microscopically hypercellular areas of spindle shaped cells with nuclear palisading Antony A pattern hematoxylin eosin stain original
  • H E and stains Post treatment changes post hydroxyurea bone marrow biopsy shows slightly hypercellular marrow with numerous megakaryocytes 1 2 megakaryocytes are often small with hypolobulated nuclei post interferon 54 year old man
  • various images bone marrow biopsy increased megakaryocytes 1 2 many megakaryocytes are unusually large 3 4 in mildly hypercellular marrow of 66 year old woman with platelet count of 1200K bone marrow smear increased megakaryocytes 1
  • Lobular capillary hemangioma
  • Micro images peripheral blood pseudo Pelger Huet cell bone marrow biopsy slightly hypercellular for a 53 year old man marked erythroid hyperplasia prominent megakaryocytes but no increase in their number bone marrow smear two post mitotic erythroid precursors
  • Lobular capillary hemangioma
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  • hypercellular marrow with panmyeloid hyperplasia and moderate adipocytes hypercellular marrow with increased megakaryocytes 1 2 3 showing primarily neutrophils PAS stain 1 shows perivascular and peritrabecular accentuation of promyelocytes and myelocytes lighter staining compared to darker staining neutrophils 2 shows promyelocytes and
  • 6 chronic phase bone marrow biopsy hypercellular marrow with panmyeloid hyperplasia and moderate adipocytes hypercellular marrow with increased megakaryocytes 1 2 3 showing primarily neutrophils PAS stain 1 shows perivascular and peritrabecular accentuation of promyelocytes and

Videos

  • LASIK, The Flap Never Heals This results in a weak, central and paracentral hypocellular primitive stromal scar that averages 2.4% as strong as normal comeal stroma. In contrast, the more superficial, flap margin stromal LASIK wound, which is adjacent to the surface epithelium, was found to heal by producing a 10-fold stronger, hypercellular fibrotic stromal scar that reaches maximum tensile strength by approximately 3.5 years after surgery, averaging 28.1% of normal.