Avoiding Blood Clots: Low Molecular Weight Heparin View more videos at: HSC 404 - Someone has a stroke every 45 seconds. This program explores the risk factors and symptoms of a stroke and when to get help. Our program delves into how strokes are treated and the many avenues for rehabilitation.
Important Changes for Heparin FDA is notifying healthcare professionals and patients about a new USP monograph for heparin. Under the new monograph, the reference standard used to determine the potency of the drug will be changed in order to make it compatible with the WHO International Standard. Despite these changes in the reference standard, heparin dosages will continue to be expressed in USP units. Partly in response to the recent heparin contamination problem, the new monograph also includes additional test methods that can detect potential impurities and contaminants. As a result of the change in the reference standard, the potency of heparin marketed in the US will now be reduced by about 10 percent, so, there could be up to a 10 percent decrease in heparin activity for each USP unit administered. This means that some patients may require more heparin to achieve and maintain the desired level of anticoagulation. Patients may also require more frequent or intensive monitoring of aPTT or ACT. This could be especially significant in some situations - for example, when heparin is administered as a bolus IV dose and it is important to achieve an immediate anticoagulant effect. The changes in heparin potency may not be clinically significant when it is given subcutaneously, because the drug's bioavailability is lower and more variable when it's administered this way. Manufacturers began shipping the new heparin product in early October. For a while, both products will be available at the same time ...
Delayed Onset of Heparin-induced Thrombocytopenia (Feb. 07) FDA is alerting healthcare professionals that the onset of heparin-induced thrombocytopenia (HIT) can be delayed in patients who had previously been treated with heparin sodium injection. HIT results from an irreversible aggregation of platelets. About half the time, it can lead to development of venous and arterial thromboses, a condition called heparin-induced thrombocytopenia and thrombosis (HITT). If this occurs, serious thrombotic complications can include pulmonary embolism, stroke, MI, skin necrosis, gangrene and even death. New warnings in the drug label point out that HIT, with or without thrombosis, can occur up to several weeks after heparin therapy is stopped. So patients who present with thrombocytopenia or thrombosis after they discontinue heparin should be evaluated for HIT and HITT. Heparin should not be administered to these patients until their platelet count is checked, because giving heparin to these patients could cause serious or even fatal reactions. Additional Information: FDA MedWatch Safety Alert. Heparin Sodium Injection. December 8, 2006. www.fda.gov
ANTI-COAGULANT THERAPY - HEPARIN INJECTIONS ANTI-COAGULANT THERAPY - HEPARIN INJECTIONS - Department of Defense 1978 - PIN 31336 - DEMONSTRATES AN IMPROVED SUBCUTANEOUS HEPARIN INJECTION PROCEDURE. GIVES CLINICAL INDICATIONS, CONTRAINDICATIONS, PHARMACOLOGICAL ACTION, ADVANTAGES, DISADVANTAGES, SIDE EFFECTS AND ANTIDOTES FOR HEPARIN THERAPY.
Heparin Recall Information If you've been hurt by heparin, you may be entitled to a cash settlement. In December 2007, the FDA recalled a shipment of heparin because of a growth of Serratia marcescens in several unopened syringes of this product. The bacteria Serratia marcescens can lead to life-threatening injuries and death. In March 2008, major recalls of heparin were announced by the FDA due to contamination of the raw heparin stock imported from China. The FDA admitted that it had violated its own policies by failing to inspect the American pharmaceutical firm Scientific Proteins plant in China before approving the drug for sale. The US Food and Drug Administration was quoted as stating that at least 81 deaths were believed linked to a raw heparin ingredient imported from the People's Republic of China, and that they had also received 785 reports of serious injuries associated with the drugs use. According to the New York Times, "Problems with heparin reported to the agency include difficulty breathing, nausea, vomiting, excessive sweating and rapidly falling blood pressure that in some cases led to life-threatening shock." The contaminant has been identified as an "over-sulphated" derivative of chondroitin sulfate, a popular shellfish-derived supplement often used for arthritis. Since this "over-sulphated" variant is not naturally occurring and mimics the properties of heparin,the counterfeit is almost certainly intentional as opposed to ...
Heparin Recalls Fox Business Happy Hour - Jeremy Discusses how America's lead over China in science, medicine and industry translates into valuable opportunities for American Business
Doctor: Too Much Heparin Causes Internal Bleeding Carol Kloss reports.
Savilla's hope - Heparin Administration of heparin in patients with kidney failure on peritoneal dialysis. Heparin is a naturally-occurring anticoagulant produced by basophils and mast cells. Heparin acts as an anticoagulant, preventing the formation of clots and extension of existing clots within the blood. While heparin does not break down clots that have already formed (unlike tissue plasminogen activator), it allows the body's natural clot lysis mechanisms to work normally to break down clots that have already formed.
Heparin Contaminated If you've been hurt by heparin, you may be entitled to a cash settlement. Background There is an urgent need to determine whether oversulfated chondroitin sulfate (OSCS), a compound contaminating heparin supplies worldwide, is the cause of the severe anaphylactoid reactions that have occurred after intravenous heparin administration in the United States and Germany. Methods Heparin procured from the Food and Drug Administration, consisting of suspect lots of heparin associated with the clinical events as well as control lots of heparin, were screened in a blinded fashion both for the presence of OSCS and for any biologic activity that could potentially link the contaminant to the observed clinical adverse events. In vitro assays for the activation of the contact system and the complement cascade were performed. In addition, the ability of OSCS to recapitulate key clinical manifestations in vivo was tested in swine. Results The OSCS found in contaminated lots of unfractionated heparin, as well as a synthetically generated OSCS reference standard, directly activated the kininkallikrein pathway in human plasma, which can lead to the generation of bradykinin, a potent vasoactive mediator. In addition, OSCS induced generation of C3a and C5a, potent anaphylatoxins derived from complement proteins. Activation of these two pathways was unexpectedly linked and dependent on fluid-phase activation of factor XII. Screening of plasma samples from various species ...
Heparin . . . The forgotten hero in myocardial infarction How do you manage a elderly person with Myocardial infarction ?
ADMIN SQ INJECTIONS HEPARIN AND OTHERS
Baxter Recalls Heparin Syringes If you've been hurt by heparin, you may be entitled to a cash settlement. The FDA has conducted an investigation at both of these plants, as well as a facility owned by one of Baxter's subsidiaries in New Jersey, where the finished heparin is packaged, although this facility has now all but been ruled out of the agency's investigation. Folowing the FDA's press briefing, SPL issued a statement maintaining that "thus far, no conclusions have been reached about the root cause. It is premature to conclude that the heparin API sourced from China and provided by SPL to Baxter is responsible for these adverse events". "During the call with the media, FDA speculated that the source of the adverse events may be a contaminant. It is important to note that this theory is speculation at this point, and SPL is participating actively in working with the FDA to pursue this theory as well as others so that we can understand the cause of the adverse events".
FDA Never Inspected Chinese Heparin Plants If you've been hurt by heparin, you may be entitled to a cash settlement. Additional details about Baxter Healthcare Corporations, urgent recall of Heparin, a prescription injectable blood coagulant often used in hemodialysis (the filtering of blood) and cardiac invasive procedures, on January 25th 2008 are now being released. The Food and Drug Administration (FDA) has reported that it never inspected the Chinese manufacturing plant that provides Baxter with the active ingredient of the drug. FDA admission According to several news sources, the FDA, already under scrutiny for not adequately protecting the public against many harmful drugs and defective medical devices, admitted that it did not inspect the Chinese plant that provides Baxter with Heparins active ingredient an enzyme taken from pig intestines which has been linked to several adverse reactions to the drug. The active ingredient is shipped to a Baxter facility in New Jersey where the final manufacturing process is completed. Baxter has reported that it inspected the plant outside of Shanghai, China less than months beforehand and that it plans to inspect it again based on this latest report.
Baxter Recalls Heparin Syringes If you've been hurt by heparin, you may be entitled to a cash settlement. Actor Dennis Quaid's twelve-day-old twins mistakenly were given an adult dosage, which is 1000 times the recommended dosage for infants, in November 2007. The overdose allegedly arose because the labeling and design of the adult and infant versions of the product were easily confused. The Quaid family subsequently sued the manufacturer, Baxter Healthcare Corp., for over $50000. In July 2008, another set of twins born at Christus Spohn Hospital South, a Texas hospital, died after an accidentally administered overdose of the drug. The overdose was due to a mixing error at the hospital pharmacy and, unlike the Quaid case, was unrelated to the product's packaging or labeling. As of July 2008[update], whether the deaths were due to the overdose is under investigation.
Contaminated Heparin Recall If you've been hurt by heparin, you may be entitled to a cash settlement. The head of the US Food and Drug Administration (FDA), Andrew von Eschenbach, said that he believes that the raw heparin supply to the United States may have been tainted due to economic fraud. The FDA has attributed 62 deaths to allergic reactions from raw heparin obtained from China. FDA comments Eschenbach told an Senate Appropriations Committees agricultural subcommittee that he believes the contaminated heparin supply to the United States contained oversulfated chondrotin sulfate, an altered version of chondrotin sulfate made from animal cartilage often found in dietary supplements. He claims that economic fraud may have been involved as the altered version is similar to the active ingredient in heparin, but less expensive to produce. The raw ingredient in heparin is derived from pig intestines.
Heparin Recall If you've been hurt by heparin, you may be entitled to a cash settlement. Symptoms associated with the drug Baxter has advised that the following symptoms may be associated with the drug some of which may be life threatening Discomfort, vomiting, diarrhea, decreased or low blood pressure, chest and stomach pain, fast heart rate, dizziness, fainting, unresponsiveness, nausea, shortness of breath, feeling your heart beat strong or fast, drug ineffectiveness, burning sensation, redness or paleness of skin, abnormal sensation of the skin, mouth or lips, flushing, increased sweating, decreased skin sensitivity, headache, feeling unwell, restlessness, watery eyes, throat swelling, thirst and difficulty opening the mouth.
Heparin Recall If you've been hurt by heparin, you may be entitled to a cash settlement. Heparin-induced thrombocytopenia (HIT) with or without thrombosis (HITT) is thrombocytopenia (low platelet counts) due to the administration of heparin. While it is mainly associated with unfractionated heparin (UFH), it can also occur with exposure to low-molecular weight heparin (LMWH), but at significantly lower rates. Despite the low platelet count, it is a thrombotic disorder, with very high rates of thrombosis, in the arteries with or without venous complications. Of note, the rate of DVT (deep vein thrombosis) is roughly 4 times that of arterial thrombosis, and while thrombocytopenia is the most common "event" in HIT, DVT is in fact the most common complication. HIT typically develops 4-14 days after the administration of heparin. Heparin (UFH) is used in cardiovascular surgery, as prevention or treatment for deep-vein thrombosis and pulmonary embolism and in various other clinical scenarios. LMWH is increasingly used in outpatient prophylaxis regimes. There are two forms of HIT. Type II HIT is the main adverse effect of heparin use.
Recall On Heparin If you've been hurt by heparin, you may be entitled to a cash settlement. Whos to blame? That question is still being considered. Many of the large heparin suppliers such as Baxter Healthcare, B. Braun Medical and Covidien obtain their raw heparin from Scientific Protein Labs (SLP) a Wisconsin based company with plants in China. However, that company doesnt seem to be involved in the fraud. Rather, fingers seem to point to the suppliers of the raw heparin in China those involved even before it reaches the Chinese factories owned by SLP. Uncertainty remains Even with this new information, the FDA says that it still isnt absolutely certain whether the contaminated heparin is directly responsible for the increase in deaths over the product, a prescription injectable blood thinner used in cardiac procedures. Eschenbach told the committee that the FDA inspects some of the Chinese factories, but rarely does a second inspection. He said that he hopes to open up additional FDA offices in China by October 2008, as well as offices in other parts of the world that provide the United States with food and drugs to correct that problem.
Heparin Induced Thrombocytopenia
More Heparin Dosing Errors with Neonates (Dec. 2008) The Institute for Safe Medication Practices (ISMP) reports that serious dosing errors continue to occur when heparin is administered to neonates. ISMP cites an incident in Texas where as many as 17 infants in a neonatal intensive care unit received heparin overdoses. According to ISMP's ***ysis, the infants may have received up to 100 times more heparin than intended. ISMP notes that when preparing solutions in the pharmacy, calculation errors are especially prone to occur when heparin is stocked in unfamiliar concentrations eg, for example, if the pharmacy were to switch from vials containing 1000 units per mL to vials containing 10000 units per mL. The possibility of a dosing error increases if the pharmacy fails to verify the concentration of a solution before dispensing. Another problem, according to ISMP, is that there is no standard dosing protocol when it comes to using heparin for maintaining the patency of venous and arterial lines in neonates. This means a hospital might have to stock heparin solutions in several concentrations ranging from 0.5 units per mL to 10 units per mL, and this can make errors more likely. In this report and an earlier one, ISMP offered several suggestions to help avoid these potentially tragic errors. For example, the pharmacy could prepare and dispense heparin flush solutions, rather than having nurses do this in patient care areas. Or a hospital could consider using pre-filled heparin flush syringes, which are now available in ...
Preventing Fatal Heparin Overdoses (Dec. 2006) The Institute for Safe Medication Practices recently cited a case in which three premature infants died after receiving an overdose of heparin. According to ISMP, this may have occurred because heparin vials containing 10000 units/mL were placed in an automated dispensing cabinet where vials containing 10 units of heparin per ml were normally kept. The vials looked somewhat similar, and the nurses did not notice that the ones that were taken from the cabinet actually contained 10000 times more heparin than they expected. ISMP notes that errors in filling automated dispensing cabinets are common, and so it is important to double-check the contents of these cabinets before they leave the pharmacy. The ISMP Alert lists several other steps to help prevent these kinds of errors. For example: • Consider which medications might be removed from automated dispensing cabinets for safety's sake, especially in those cabinets that are used for high-risk patients such as neonates and children. • Take steps to minimize look-alike packages and labels. When possible, do not stock items on nursing units that require further preparation before administration. • Consider bar coding for medication administration management systems throughout the hospital, if not already in place. Even if bedside scanning is not being used, dispensing cabinet vendors provide bar code systems to make sure the right medications are stocked in these cabinets. Additional Information: ISMP Medication Safety Alert ...
More Than You Ever Wanted To Know About Heparin Heparin is an anticoagulant. It also has many other important physiological functions. This film serves as an introduction to the molecular structure of heparin.
Baxter Sued Over Contaminated Heparin If you or a loved one has been hurt by heparin, you may be entitled to a cash settlement. A Texas family has filed a lawsuit against Baxter International and its suppliers and distributors after one of their family members was allegedly given contaminated heparin, suffered a brain hemorrhage and died. This is the latest in a series of lawsuits over the contaminated product that, according to the US Food and Drug Administration (FDA), has been linked to over 80 deaths and nearly 800 adverse effects. The latest lawsuit According to several news reports, Texas resident Debra Spivey was allegedly injected with contaminated heparin, a drug used to thin the blood and prevent clotting, while in the hospital. She suffered a brain hemorrhage and died. Her family filed a product liability lawsuit against Baxter International, the drugs manufacturer, Scientific Protein Laboratories, the company who obtains the raw heparin for Baxter from China and American Capital Strategies, an asset management company. The lawsuit alleges negligence, defective design, manufacturing defect, failure to warn, breach of implied and express warranties, violation of the Texas Deceptive Trade Practices Act and more.
Chad Cook on Heparin Recall Chad Cook explain the dangers of the blood thinner Heparin. Widely used as an injectable anticoagulant and it derived from pig intestines, Heparin recently came under scrutiny after tainted heparin stock imported from china led to six major recalls of the medicine. The FDA reported 785 serious injuries and 395 death linked to Heparin. 450000 patients are on dialysis in the US and the vast majority use this blood thinner. Beasley Allen is investigating claims where patients have died or have any other catastrophic injury caused by Heparin.
Heparin-binding EGF-like Growth Factor Increases Intestinal Microvascular Blood Flow... Dr. Gail E. Besner discusses her m***cript Heparin-binding EGF-like Growth Factor Increases Intestinal Microvascular Blood Flow in Necrotizing Enterocolitis. To view the print version of this abstract go to
Heparin If you or a loved one has been hurt by heparin, you may be entitled to a cash settlement. An FDA investigation in both the United States and abroad included inspecting Baxter's domestic facilities, examining Heparin products in the United States and sending a team of experts to China to conduct a comprehensive inspection of the Changzhou SPL facility that makes the active ingredient for the drug. The FDA says at this point it is unclear how the Heparin-like compound got into the Heparin Active Pharmaceutical Ingredient, but they are continuing to investigate the situation. The FDA has issued a warning to the Chinese supplier of raw Heparin for Baxter, for failing to ensure its manufacturing process removes impurities. The supplier Changzhou SPL says it will cooperate with the agency. Allergic reactions, or low blood pressure, have also been reported after patients received Heparin, including Baxter's product. The drug Heparin is used in kidney dialysis and various surgeries to prevent blood clots, and allergic reactions, or low blood pressure, have also been reported following patients receiving Heparin. The FDA says that the Heparin currently sold in the United States was being tested and was safe and the recent increase in Heparin reactions were only reported in Germany and the United States. The Heparin scare is just the latest in a succession of recalls involving products from China, including contaminated pet food, excessive lead in paint on ...
Heparin Injections for Leiden Factor V during Pregnancy I have a genetic blood-clotting disorder called Leiden Factor V. Because of this I am at even greater risk for clots than the average pregnant woman. The fear is not only that I am in danger of throwing a clot, but also that a clot could form in the umbilical cord thus cutting off oxygen to the baby. The preventative measure? Heparin injections. During my pregnancy (and 6 weeks after) I had to give myself shots in the stomach: 2 in the morning and 2 at night. The reason it was 4 a day in stead of two is because none of the local pharmacies carried pre-loaded syringes with the quantity I needed so I was forced to use two needles. Instead of using Heparin my sister was able to use Lovenox. It is much more expensive but it is more concentrated (1 injection per day) and it doesn't sting nearly as bad going into the bodies tissues. My insurance wouldn't cover that one. So it was 4 injections per day for me. The final count? 4 injections a day times 37 weeks equals... over 1, 040 injections. What does that look like? Watch the video.
Heparin Blood Thinners Could Kill You! A delayed recall of tainted Heparin by Tyco healthcare has resulted in 81 deaths so far. Tyco is now being sued for their irresponsible actions.
Heparin SubQ by Jenny & Susie This our version of heparin hope you enjoy it! One thing we would like to mention, heparin subQ is choice of drug for pregnant women but not in their third trimester.
Heparin Overdose Kills Girl At Hospital Ryan Luby reports.
Recall of Heparin and Saline Flush Syringes Here is an alert about a nationwide recall of all heparin and normal saline flushes manufactured by AM2 PAT, Inc. These pre-filled syringes are distributed under two brand names: Sierra Pre-filled and B. Braun. Some of the syringes have been found to be contaminated with Serratia marcescens, which has caused patient infections that can be serious and even fatal. All sizes and strengths of these heparin and saline flushes are being recalled. If you have any of these syringes, stop using them immediately. Quarantine them and return them to your distributor. For questions, contact the company at 919-552-9689. FDA Patient Safety News: March 2008 For more information, please see our website: www.accessdata.fda.gov
Heparin Recall Information TV advertisement about Heparin Recall from Audet & Partners, LLP
Heparin Induced Thrombocytopenia
Heparin Recall | Contaminated Heparin Recall Video | Heparin Attorney, Lawyer, Lawsuit Video provides information on recalled Heparin. There have been multiple Heparin recalls issued by a large number of manufacturers due to the chance that their products may contain contaminated Heparin. Learn more about the Heparin recall by visiting our website:
Heparin If you've been hurt by heparin, you may be entitled to a cash settlement. Health officials in the US appear to be at loggerheads with Chinese officials over the contamination of the blood-thinning drug Heparin. According to the Food and Drug Administration (FDA) they have new evidence linking a contaminant to deaths and allergic reactions in patients who took the blood-thinner Heparin which were made with ingredients from China. The adverse events have included allergic or hypersensitivity-type reactions, with symptoms such as low blood pressure, shortness of breath, nausea, vomiting, diarrhea and abdominal pain. Chinese officials have rejected the allegations and say that the chemical concerned was not the culprit. The FDA says new data from research showed the contaminant, over-sulfated chondroitin sulfate, could trigger side effects such as those reported in the deaths of 81 Heparin patients. In February this year drug company Baxter International was forced to recall most of its Heparin products made with ingredients from China following five deaths which were suspected to be linked to the chemical which originated from China.
FDA feels the heat over heparin Apr 22 - The FDA was in the hot seat on Capitol Hill after a tainted drug was implicated in multiple deaths.A recent study found that more than 80 percent of active ingredients in US drugs come from abroad, but only 11 percent of foreign suppliers are investigated by the borah Lutterbeck reports.
Avoiding Dangerous Mix-ups with Insulin & Heparin (July 07) The New Jersey Department of Health and the Institute for Safe Medication Practices (ISMP) have each recently warned about several different ways that dangerous mix-ups can occur between insulin and heparin. Some of these mix-ups happened when patients receiving total parenteral nutrition had insulin added to their TPN bags instead of heparin. In one case, a premature infant in the NICU had a blood glucose level of 17 mg/mL several hours after being started on a TPN infusion. Despite multiple administrations of dextrose, the hypoglycemia did not completely resolve until TPN was stopped. A later ***ysis showed that the fluid contained insulin, not heparin. This infant's long term outcome has not yet been determined, and ISMP describes two similar incidents where the babies died. These kinds of errors can happen other ways. For example, two patients who were not diabetic died after being injected with insulin instead of heparin during a vascular catheter flush procedure. In a different case, a nurse erroneously transcribed a verbal order to resume an insulin drip as "resume heparin drip." And in yet another case, a pharmacist entered an order for heparin 500 units into the computer as "regular insulin 500 units." ISMP says several factors contribute to these mix-ups. First, the 10 mL vials of insulin and heparin often look similar. Both insulin and heparin are typically used every day during each shift, so these similar-looking vials are often next to each other on a ...
Heparin-Induced Thrombocytopenia Learn more about the deadly disease that causes platelets to clot from an anticoagulant! Brought to you by David W. Woodruff, MSN, RN-BC, CNS, CEN and www.ed4.
Heparin-Induced Thrombocytopenia (HIT) View this Lecture for FREE by signing up at Viewany number of our other 28000 sessions from over 280 conferences by going to Speaker(s) Troy Plumb, MD, FACP, FASN Heparin-Induced Thrombocytopenia (HIT) - American Nephrology Nurses Association National Symposium 2008 Nephrology Nursing and Evidence-Based Practice: In Harmony to Improve Patient OutcomesRemember, if you attended this meeting you have Free Access to this content! Click here for more information.All invited faculty members and planning committee members participating in an ANNA-sponsored program are required to disclose any real or apparent conflict(s) of interest that may have a direct bearing on the subject matter of the educational activity. To review speaker disclosures, click hereThe presence of any product, company, or corporation in any recording or content in no way signifies an endorsement of the product, company or corporation by ANCC Commission on Accreditation or the American Nephrology Nurses' Association (ANNA).Contact Hours available through: 6/1/2010Please note: Learners may earn contact hours (for recertification or relicensure) for each educational activity once only. If you attended a session at a live meeting (National Symposium, Fall Meeting, Audio Conference, etc.), you cannot repeat and claim credit for that session again. While the session is now offered online in a different format, the educational content is the same. Heparin-induced ...
Illness & Death Resulting From Heparin If you have been prescribed heparin, you could be at risk! If any sickness or trauma has been a part of your life due to heparin, contact a lawyer today! In December 2007, the FDA recalled a shipment of heparin because of a growth of Serratia marcescens in several unopened syringes of this product. The bacteria Serratia marcescens can lead to life-threatening injuries and death. In March 2008, major recalls of heparin were announced by the FDA due to contamination of the raw heparin stock imported from China. The FDA admitted that it had violated its own policies by failing to inspect the American pharmaceutical firm Scientific Proteins plant in China before approving the drug for sale.
heparin lock insertion when i was at the hospital they inserted a really long and big needle into me and just taped it there.. its called a heparin lock.. its where they inject dye into my veins for my ct scan.. hurt like hell
Tanveer Zamani, MD - Heparin Induced Thrombocytopenia, Chicago 2004 Tanveer Zamani, MD - Heparin Induced Thrombocytopenia. Grand Round - Surgical Critical Care, Chicago, 2004