The Human Genome: Human Genetics and the Brain Dr. Louis Ptacek's research focuses on identification and characterization of genes that cause normal variations and disorders of the nervous system. Series: "UCSF Mini Medical School for the Public" [7/2006] [Health and Medicine] [Show ID: 11682]
Neanderthal Genome Sequence Interview with Jim Mullikin, Ph.D. May 5, 2010 - Interview with Jim Mullikin, Ph.D., Acting Director NIH Intramural Sequence Center. For more information: www.genome.gov
Genome Sequencer FLX System Workflow Video highlights of the Genome Sequencer FLX System sample preparation workflow. The FLX instrument is a ultra-high throughput DNA sequencer developed by 454 Life Sciences, A Roche company.
bit shifter - hexadecimal genome (8bit) artist: bit shifter title: hexadecimal genome www.8
Musical genome A collaboration between scientists and a composer is making sweet music -- and may help identify the genes that relate to musical ability
Genome-Wide Association Studies Science Reporters' Seminar on Genome-Wide Association Studies ( genome.gov ) Teri Manolio, MD, Ph.D. Senior Advisor to the Director for Population Genomics
What is a Genome A genome is all of a living thing's genetic material. It is the entire set of hereditary instructions for building, running, and maintaining an organism, and passing life on to the next generation. The whole shebang. AGTCCGCGAATACAGGCTCGGT In most living things, the genome is made of a chemical called DNA. The genome contains genes, which are packaged in chromosomes and affect specific characteristics of the organism. Imagine these relationships as a set of Chinese boxes nested one inside the other. The largest box represents the genome. Inside it, a smaller box represents the chromosomes. Inside that is a box representing genes, and inside that, finally, is the smallest box, the DNA. In short, the genome is divided into chromosomes, chromosomes contain genes, and genes are made of DNA. 46 for Human Adults and 48 for Great Apes. However, Human chromosome#2 is our fused ape chromosome. Each one of earth's species has its own distinctive genome: the dog genome, the wheat genome, the genomes of the cow, cold virus, bok choy, Escherichia coli (a bacterium that lives in the human gut and in animal intestines), and so on. So genomes belong to species, but they also belong to individuals. Every giraffe on the African savanna has a unique genome, as does every elephant, acacia tree, and ostrich. Unless you are an identical twin, your genome is different from that of every other person on earth—in fact, it is different from that of every other person who has ever lived. Though ...
HGSI Human Genome Sciences FDA Panel Review Selling off on Rumors and Speculation HGSI Human Genome Sciences FDA Panel Review Selling off on Rumors and Speculation on Benlysta Lupus Drug "Suicide Rate" Risks. Human Genome Sciences (NASDAQ HGSI) opened at $26.00 after trading as high as $29.50 in "pre market trading". today, the stock has hit a low of $23.68 and a high of $26.24 3.7X High Trader volume as over 10 million shares of trading so far today with another 1 hour and 50 minutes of trading remaining. The stock is down 9.86% as we wait to see how the results for Benlysta are received by the FDA. The "wall street" media hypsters are at it again indicating that the HGSI FDA Panel Review results were "surprising" and we believe there is no additional information in the FDA Panel Review that would have us change our stance on the equity. Human Genome Sciences Lupus Drug FDA Program Schedule Assuming the Worst Market Manipulation? Human Genome Sciences Pre Market Gap FDA Benlysta News Pending (HGSI). HGSI had increased price action and volatility as the stock spiked to $29.48 in pre market trading as the FDA released it's 133 page FDA Briefing Information, Belimumab (BENLYSTA), for the November 16, 2010 Meeting of the Arthritis Advisory Committee which addressed Guidance for Industry:Systemic Lupus Erythematosus -- Developing Medical Products for Treatment, Guidance for Industry: Lupus Nephritis Caused by Systemic Lupus Erythematosus -- Developing Medical Products for Treatment, Draft Guidance for Industry: Suicidality ...
Richard Dawkins: Comparing the Human and Chimpanzee Genomes - Nebraska Vignettes #3 Richard Dawkins shows just how similar the Human and Chimpanzee genomes really are, with the help of a great visual from the University of Nebraska Museum. Download Quicktime version (720p HD): Get the RDF TV podcast through iTunes! If you enjoy the video, and would like to help us make more videos like this, please consider donating $1 (or any other amount you'd like) to The Richard Dawkins Foundation for Reason and Science: During Richard Dawkins' 2009 American tour, we visited Judy Diamond's "Explore Evolution" exhibit at the University of Nebraska State Museum in Lincoln. This exhibit has now been replicated in six museums around the country. While visiting we filmed a collection of short unrehearsed and unscripted videos—just inspired by the "Explore Evolution" exhibit. See the "Explore Evolution" web page here: explore-evolution.unl.edu Special Thanks to: Dr. Judy Diamond The University of Nebraska State Museum Camera & Music by Josh Timonen See more at:
Adventures in the Cancer Genome Richard Wilson, Ph.D. Washington University School of Medicine NIH Intramural Sequencing Center 10th Anniversary Symposium Genome Exploration by Large-Scale DNA Sequencing: Circa 2007 and Beyond Tuesday, October 16, 2007 Masur Auditorium Building 10, Clinical Center National Institutes of Health Bethesda, Maryland More: www.genome.gov
Positive Selection: Is the Human Genome Evolving? Complete video at: fora.tv UCSF biostatistics professor Dr. Katherine Pollard describes The Chimp Genome Project, which lists 15 genes associated with human diseases that originate in chimps. While some people have the "new human version" of the gene, others still have the "chimp version." Evidence, she claims, that humans are evolving away from their ancestral version. ----- We are in the midst of a renaissance in the biological sciences, which is spurring the growth of brand new fields like functional and comparative genomics. These new fields are revealing novel insights into evolutionary biology, medicine, developmental biology and many other areas, transforming the way scientists look at life. Join the California Academy of Sciences to learn about genomics, hear about compelling current research, and explore the future of this rapidly advancing field. - California Academy of Sciences Katherine Pollard received her Ph.D. and MA from UC Berkeley Division of Biostatistics under the supervision of Mark van der Laan. Her research at Berkeley included developing computationally intensive statistical methods for ***ysis of microarray data with applications in cancer biology. After graduating, she did a postdoc at UC Berkeley with Sandrine Dudoit. She developed Bioconductor open source software packages for clustering and multiple hypothesis testing. In 2003, she began a comparative genomics NIH Postdoctoral Fellowship in the labs of David Haussler and Todd Lowe in the ...
Human Genome Sciences Rise - Bloomberg Human Genome Sciences Shares Jump on Rumored GlaxoSmithKline Bid (Bloomberg News)
Beyond the Genome: DNA Is Not Destiny Renowned geneticist Dr. Victor Corces's lecture "Beyond the Genome: DNA Is Not Destiny" was given as part of Emory University's Life of the Mind lecture series. The series showcased Emory's leading faculty members each month during the spring of 2009. For more information on Dr. Corces, visit www.biology.emory.edu And for more information on the Life of the Mind series, please visit www.emory.edu
Platypus Genome: by Nature Video The duck-billed platypus is a truly unique animal; a monotreme with almost no close relatives alive on earth. Scientists just had to take a look at that genome and here they discuss their findings. Watch researchers discuss the fascinating genome of the duck-billed platypus; an amalgam of reptilian, mammalian and unique characteristics.
Translating Genome-Wide Association Studies to Prevention, Diagnostics, and Therapeutics Science Reporters' Seminar on Genome-Wide Association Studies ( genome.gov ) Alan Guttmacher, MD Former Deputy Director, National Human Genome Research Institute
The Neanderthal Genome Project Svante Pääbo of the Max Planck Institute joins Cold Spring Harbor Laboratory's Dave Micklos to discuss Neanderthal genetics. Dr. Pääbo looks at mating between humans and Neanderthal, the FOXP2 gene and language development, and the possibility of recreating a Neanderthal today.
The Human Genome: A Decade of Discovery, Creating a Healthy Future (PM Session - Part 2) June 7, 2010 - Science Reporters Workshop to help science reporters write stories about the 10th anniversary of the completion of the draft sequence of the human genome (on June 26, 2000) and to look at the future of genomic research. Agenda: www.genome.gov
What is a Genome? Using fruit flies and small plants, USC professor researches the route from genotype to phenotype to understand more about disease states in humans.
Ken Miller Human Chromosome 2 Genome The phases through which chromosomes replicate, divide, shuffle, and recombine are imperfect, as DNA is subject to random mutations. Mutations do not always produce harmful outcomes. In fact, many mutations are thought to be neutral, and some even give rise to beneficial traits. To corroborate Darwin's theory, scientists would need to find a valid explanation for why a chromosome pair is missing in humans that is present in apes.
Genomes may lead to personalized vitamin supplement, 6/02/08 UC Berkeley scientists have found a welcome reason to delve into your genetic heritage: to find the slight genetic flaws that can be fixed with remedies as simple as vitamin or mineral supplements. Watch as Genetics professor Jasper Rine tells of his work with the human genome to help people "personalize" their nutritional requirements (1:41 min.) Video produced by Roxanne Makasdjian / Media Relations www.berkeley.edu
DOE JGI Whole Genome Shotgun Sequencing, part 1 A Howard Hughes Medical Institute (HHMI) video production describing the Whole Genome Shotgun Sequencing process at the US Department of Energy's Joint Genome Institute (JGI).
Aging of the Other Genome: A Decisive but Ambitious Solution Google Tech Talks December, 19 2007 The DNA in our cells consists of not only the well-known 46 chromosomes currently receiving such avid attention from specialists in sequencing technology, but also a large number of copies of a relatively tiny, circular DNA molecule inside the "powerhouse of the cell," the mitochondrion. Among other things, mitochondria perform the chemistry of breathing - they extract energy from nutrients by exquisitely regulated chemical reactions that consume oxygen and create CO2. This vital function depends on the 13 proteins encoded by the mitochondrial DNA (mtDNA), as well as on hundreds of proteins that are encoded in our more famous genome and imported across the mitochondrial surface after construction in the body of the cell. The mtDNA accumulates mutant, non-functional variants far faster than our main genome, so 20 years ago scientists began looking at the idea of putting copies of the 13 genes of interest into the nucleus after making modifications that would cause them to be processed by the same "protein import" machinery that processes the mitochondrion's many other proteins, thus making the mtDNA itself superfluous and mutations in it harmless. I will discuss this concept in detail in my talk. Progress has been very erratic in the meantime but is now very rapid, partly because of Methuselah Foundation-funded research. However, this approach may still prove impossible, so many other, ostensibly simpler ideas - some more ...
Code For Life: The Human Genome Science & Reason on Facebook: Code For Life (Chapter 1): The Human Genome - The Cassiopeia Project. --- Please subscribe to Science & Reason: • • • • --- The Cassiopeia Project is an effort to make high quality science videos available to everyone. If you can visualize it, then understanding is not far behind. Code for Life: Beginning more than three and a half billion years ago, a tiny, primitive molecule encoded instructions deep within itself. Then it passed these instructions on to its children, who passed it to their children and so on - all the way down through time to all living things today. The human genome, written in a code of just four letters, tells us who we really are - and that generates many questions! Is this process of natural selection coming to an end? Should we choose the best that is in us for our children? If so, who gets to decide what is meant by "the best that is in us"? From amino acids in space to human genes in corn ... THIS is the story. .
Mendel - From the Garden to the Genome Film biography of Gregor Mendel (1822-1884), the Moravian monk who became the father of modern genetics through his study of pea plants. One of a series of medical history films by J. Lee Sedwick, MD, FACS, Clinical Professor of Surgery, East Carolina University, and Larry Gardner, President of Digifonics, Inc.
GENOME: The Future Is Now WEBISODE 1 Meet George Church, founder of the Personal Genome Project. GENOME: THE FUTURE IS NOW, a multi-media documentary project with a film and interactive website, has exclusive access to Harvard scientist Dr. George Church and his Personal Genome Project (PGP) in which he unlocks the genome sequences of the first ten volunteers offering themselves up as guinea pigs, pioneers, genomic astronauts for an unprecedented experiment at the crossroads of science, health, and ethics. Visit us online at /genome.html
Genome Music The day (in 2001) the genome sequence became available, Todd Barton 'sonofied' the sequence. Todd is the music director of the Oregon Shakespeare Festival. Hear & learn more at .
Spotlight - Human Genome Sciences - Bloomberg Human Genome Surges on Lupus Drug Study - Interview with CEO Thomas Watkins (Bloomberg News)
Looking for the Good News in Your Genome: Personalized Medicine—Science and Ethics December 4, 2010 Nano*High lecture: Jasper Rine, Howard Hughes Professor & Professor of Genetics, Genomics and Development, UC Berkeley. Looking for the Good News in Your Genome: Personalized Medicine—Science and Ethics. The Materials Sciences Division at the University of California's Lawrence Berkeley National Laboratory invites you and your students to Nano*High, a series of free Saturday morning lectures by UC Berkeley professors and LBNL senior scientists conducting research from nanoscience to molecular medicine, and climate change to astrophysics.
Mining Data from Genome Browsers February 02, 2010. Tyra Wolfsberg, Ph.D. Current Topics in Genome ***ysis 2010 Handout: www.genome.gov More: www.genome.gov
Evolution Human Genome The private biotech firm Celera changed the rules of gene sequencing. The company's so-called "shotgun" technique allowed Celera to sequence the entire genome in eight months -- a feat that took the HGP several years to achieve. As its name suggests, however, the shotgun technique is less than meticulous. While the HGP's traditional method kept track of where each decoded segment came from, Celera's method required that all of the randomly separated pieces of the genome be painstakingly reassembled. This not-inconsequential step took Celera supercomputers another seven months to achieve. Even so, the total time it took the company to map the genome was faster than anyone could have imagined.
The Human Genome: A Decade of Discovery, Creating a Healthy Future (PM Session - Part 1) June 7, 2010 - Science Reporters Workshop to help science reporters write stories about the 10th anniversary of the completion of the draft sequence of the human genome (on June 26, 2000) and to look at the future of genomic research. Agenda: www.genome.gov
Obstacles to Unlocking the Human Genome Complete video at: fora.tv A panel of DNA, policy, and research experts ***yze the social implications of pharmaceutical companies and universities patenting the human genome. Ballon compares the argument against releasing genetic information to a 1961 study of cancer diagnosis. ----- Personal genomic testing (the ***ysis of the DNA of individuals) is now available for less than $400. The consequences of personal genetic testing are often debated, with advocates arguing that genetic data can lead to improved health care and critics warning that consumers may be unduly worried upon learning results. California regulations impose conditions on firms providing personal genomic testing. This symposium examines genomic testing technology, its ramifications, government regulation of the industry, and whether individuals should have their genome ***yzed. - Commonwealth Club of California Linda Avey has over 20 years of sales and business development experience in the biopharmaceutical industry in San Francisco, Boston, San Diego, and Washington, DC Prior to starting 23andMe, she developed translational research collaborations with academic and pharmaceutical partners for Affymetrix and Perlegen Sciences. Avey also spent time at Spotfire helping scientists understand the power of data visualization and at Applied Biosystems during the early days of the human genome project. The advent of high density genome-wide scanning technologies brought huge potential for significant ...
National Human Genome Research Institute Director's Report to National Advisory Council, 9/13/10 NHGRI Director Eric Green reports on institute progress — from its strategic planning process for the field of genomics to The Cancer Genome Atlas and the Human Microbiome Project — at the 60th meeting of the National Advisory Council for Human Genome Research (NACHGR). NACHGR advises the Department of Health and Human Services, the National Institutes of Health, and NHGRI on genetics, genomic research, training and programs related to the International Human Genome Project. More information on the meeting: www.genome.gov NHGRI Director's Page: www.genome.gov
The Human Genome Project Video - 3D Animation Introduction Human Genome Project; An introduction to the ongoing Human Genome Project. The dynamic 3D animation will take you "inside" for a close up look at the complexity of the cell. Completed in 2003, the Human Genome Project (HGP) was a 13-year project coordinated by the US Department of Energy and the National Institutes of Health. During the early years of the HGP, the Wellcome Trust (UK) became a major partner; additional contributions came from Japan, France, Germany, China, and others. See our history page for more information. Project goals were to identify all the approximately 20000-25000 genes in human DNA, determine the sequences of the 3 billion chemical base pairs that make up human DNA, store this information in databases, improve tools for data ***ysis, transfer related technologies to the private sector, and address the ethical, legal, and social issues (ELSI) that may arise from the project. Though the HGP is finished, ***yses of the data will continue for many years. Follow this ongoing research on our Progress page. An important feature of the HGP project was the federal government's long-standing dedication to the transfer of technology to the private sector. By licensing technologies to private companies and awarding grants for innovative research, the project catalyzed the multibillion-dollar US biotechnology industry and fostered the development of new medical applications. Knowledge about the effects of DNA variations among individuals can lead to ...
NOVA: Personal Genome Project The Personal Genome Project, spearheaded by George Church, the Director of Harvard's Center for Computational Genetics, aims to recruit 100000 people to offer up their DNA and personal life histories, all in an effort to further knowledge of human genetics and why we get—or don't get—diseases. Don't miss the new episode of NOVA scienceNOW, airing Wednesday, July 2 at 9pm on PBS. Watch past episodes of the program, try out interactives, and more on our Web site: /nova/sciencenow Video podcast produced by Julia Cort. Edited and narrated by Melissa Salpietra. Original footage and interviews for NOVA scienceNOW produced by Julia Cort. Stock footage provided by . NOVA is produced by WGBH in Boston. Funding for NOVA scienceNOW is provided by Pfizer, the National Science Foundation, the Howard Hughes Medical Institute, the Alfred P. Sloan Foundation, the Corporation for Public Broadcasting, and public television viewers. This material is based upon work supported by the National Science Foundation under Grant No. 0407101. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation.
Human genome sequencing-Animated tutorial The public Human Genome Project started by identifying unique marker sequences distributed throughout the genome. Then, many copies of a small section of DNA were randomly cleaved into smaller fragments, and each small fragment was sequenced. Because there were originally many copies of the DNA in question, many fragments represented the same part of the genome. These were aligned by identifying overlapping regions of the sequence, and then they were assembled into the original DNA.
Webinar: Genome-Wide Association Studies: Hunting for Genes in the New Millennium November 20, 2008. Teri Manolio, MD, Ph.D., director of the Office of Population Genomics reported the latest on GWAS results and talked about genomics and health. More: www.genome.gov
Genome-Wide Association Studies (March 09, 2010) March 09, 2010. Karen Mohlke, Ph.D. Current Topics in Genome ***ysis 2010 Handout: www.genome.gov More: www.genome.gov
Human Genome Structural Variation, Disease, and Evolution Evan Eichler, Ph.D. University of Washington NIH Intramural Sequencing Center 10th Anniversary Symposium Genome Exploration by Large-Scale DNA Sequencing: Circa 2007 and Beyond Tuesday, October 16, 2007 Masur Auditorium Building 10, Clinical Center National Institutes of Health Bethesda, Maryland More: www.genome.gov
How Big is Your Genome? Strange DNA How Big is Your Genome Strange DNA Facts This video discusses some strange facts about DNA, genes, genetics and the human genome. How large is the human genome? How does the human genome compare to a PlayStation 3. Is there such a thing as a gay gene? How are the different human races different genetically? Are mental disorders causes by genetics? How large is the human genome compared to a mouse or a grain of rice? Crystal is graduated from Texas A&M University w/ a degree in agricultural leadership and development with an emphasis on genetics and bio-chemistry. She is currently a professional model. Visit Crystal's Website This video was produced by Psychetruth © Copyright 2007 Zoe Sofia. All Rights Reserved.
Regulatory and Epigenetic Landscapes of Mammalian Genomes February 23, 2010. Laura Elnitski, Ph.D. Current Topics in Genome ***ysis 2010 Handout: www.genome.gov More: www.genome.gov