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autolysin

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  • Cellsurface bs shinshu u ac jp GIF Image file link
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  • Cluster 520 with 2 members d1h8ga b 109 1 1 A Choline binding domain of autolysin C LytA Streptococcus pneumoniae

Videos

  • antibiotics 2nd 15 minutes.mov Antibiotics for HENT - As a side note, I did not express the fact that Beta Lactam antibiotics also have a secondary effect by increasing the activity of bacterial autolysin enzymes that are used to recycle their cell wall. Because of this action, beta lactam drugs cause the bacteria to eat up their own wall at an accelerated rate, resulting in bacterial cell death.
  • antibiotics first 15 min.mov Antibiotics for HENT - As a side note, I did not express the fact that Beta Lactam antibiotics also have a secondary effect by increasing the activity of bacterial autolysin enzymes that are used to recycle their cell wall. Because of this action, beta lactam drugs cause the bacteria to eat up their own wall at an accelerated rate, resulting in bacterial cell death.
  • ß-Lactams: Mechanisms of Action and Resistance Developed and produced by Animation Description This animation starts with the explanation of bacterial cell wall synthesis, the process targeted by ß-Lactams. Structurally, most bacteria consist of a cell membrane surrounded by a cell wall and, for some bacteria, an additional outer layer. Internal to the cell membrane is the cytoplasm which contains ribosomes, a nuclear region and in some cases granules and/or vesicles. Depending on the bacterial species, a number of different external structures may be found such as a capsule, flagella and pili. In gram negative bacteria, the gap between the cell membrane and the cell wall is known as the periplasmic space. Most gram positive bacteria do not possess a periplasmic space but have only periplasm where metabolic digestion occurs and new cell peptidoglycan is attached. Peptidoglycan, the most important component of the cell wall, is a polymer made of N-acetyl muramic acid alternating with N-acetyl glucosamine which are cross-linked by chains of four amino acids. The function of the bacterial cell wall is to maintain the characteristic shape of the organism and to prevent the bacterium from bursting when fluid flows into the organism by osmosis. Synthesis of peptidoglycan and ultimately the bacterial cell wall occurs in a number of stages. One of the first stages is the addition of 5 amino acids to N-acetyl muramic acid. Next, N-acetyl glucosamine is added to the N-acetyl muramic acid to form a ...
  • A Prudent Cutter: LytC Autolysin for Pneumococcal Fratricide Some bacteria can kill its own mates and acquire their DNA in the process called "competence" . In pneumococcus, this fratricide is accomplished by the excretion of autolysins. Such activity needs be regulated prudently to avoid self-lysis. The structure of the LytC lysozyme in ternary complex with choline molecules and a peptidoglycan fragment shows unusual hook-shaped conformation with not fully exposed active site restricting the reaction only to the non-cross-linked peptidoglycan (2WWD.pdb; ref. Perez-Dorado et al. NSMB v17, p576).