Haematology Thrombotic Disorders A review of the most important thrombotic disorders effecting the human body
NEONATAL SEIZURES - FOCAL CLONIC Summary: This is a term baby delivered by SVD to a G2P1+0 lady with an uneventful pregnancy.Mother is a diabetic on diet control only. Apgar Sccore was 8 and 9 at 1 and 5 minutes respectively. Baby was doing well in the admission nursery maintaining normal blood sugar in the first 24 hours. Shortly thereafter developed focal clonic seizure activity confined mainly to Left side of the body. So was shifted to NICU. Clinically after abortion of the fit (by loading with phenobarbitone), baby was stable on room air with unremarkable physical exam. except for mild hypotonia on the affected side. Initial lab workup:CBC,Electroytes,Blood gas and CSF profile were normal. Blood, Urine and CSF C/S were negative. CT brain scan was normal. TANDM-MS was unremarkable. Protein C,S and antithrombin III were normal. MRI brain 3 days later showed Right fronto parietal cerebral infarction. Baby was discharged 2 days later with diagnosis of neonatal arterial stroke.
Pharmacology: Heparin Pharmacology Heparin Low molecular weight heparin Fondaparinux
Womens Issues and Blood Clotting Part 1 of 10 Colleen T. Morton MD , Hematology and Oncology HealthPartners Regions Hospital and HealthPartners Riverside Assistant Professor University of Minnesota discusses Womens Issues and Blood Clotting Comments: Introduction, Topics, Thrombophilia - Inherited and acquired, Factor V Leiden, Prothrombin, mutation, Protein S, Protein C, Antithrombin, Hyperhomocysteinemia, Antiphospholipid syndrome, Estrogen and the Clotting System, procoagulants, anticoagulant, (Slides 1 - 5)
Three Auto Immune Disorders Have Caused my Recurrent Miscarriages Hello everyone, here are the answers we have all been waiting for. I have three auto immune disorders. One is called antithrombin III, another is a protein C defeciency and the last one is antiphospholipid antibody syndrome. I will have to take Lovenox the next time I am pregnant so that the baby will have a fighting chance. I also think I am pregnant again!!! I took a test today and it was positive!!! FINGERS CROSSED!!!
Role of Estrogen Medical Animations by High Impact Graphics. Learn more at or give us a call at 800-749-2184.
Biophen Antithrombin 2.5 A221102 Product Information about Biophen Antithrombin 2.5
FDA Approves First Human Drug from Genetically Engineered Animals (May 2009) FDA recently approved the first biological product made from genetically engineered animals. The product, called ATryn, is an anticoagulant used to prevent blood clots in patients with a rare disease known as hereditary antithrombin deficiency. These patients can develop blood clots during high-risk situations such as surgery and childbirth. The approval gives patients with this disease an important new treatment option. ATryn is a therapeutic protein made from the milk of genetically engineered goats. These goats have had a segment of DNA introduced into their genes that causes the female goats to produce human antithrombin in their milk. FDA's approval prohibits using these animals for food or feed, and also ensures that the genetic modification is not harming the animals. The manufacturer will continue to monitor the product's safety, including the possible development of immune responses in patients who receive repeated ATryn treatments. The product is expected to be available in the second quarter of 2009.
TTC update part 2 of 2 MFM appt The Maternal Fetal Medicine Specialist has me get this bloodwork: -Protein C Activity -Protein S Activity -Antithrombin III activity -Prothrombin "Poort" [G20210A] Gene Mutation -Methylenetetrahydrofolate reductase (MTHFR) -Antithrombin III Antigen -anti-ß2-Glycoprotein IgG/IgM -Fasting Homocysteine Once I get pregnant (God willing) here is the MFM's game plan: -Baby Aspirin 1x EVERYDAY -Heparin EVERYDAY -Progesterone 100mg -bi-weekly appts -measuring my cervix -possible Cervical Cerclage after 1st trimester
3. Transgenic species (HSC biology) Covers the HSC biology syllabus dot point: "outline the processes used to produce transgenic species and include examples of this process and reasons for its use"
ATryn Available for Patients with Hereditary Antithrombin De B-roll footage of: Farm where goats are raised, ATryn processing facility, GTC scientists, Lundbeck Inc. and GTC CEOs (Video: Lundbeck Inc and GTC Biotherapeutics)
Normal Thrombus Formation Medical Animations by High Impact Graphics. Learn more at or give us a call at 800-749-2184.
Clot Formation Process and Clot Break In the previous page we examined the activation of platelets and briefly mentioned the blood coagulation reactions, which result in the conversion of fibrinogen to fibrin. Now let us pull all this together by following a typical sequence of events following a break in the wall of a blood vessel. Intact Endothelium The thin, single layer of cells than line a blood vessel is called the endothelium. (The walls of the smallest vessels, the capillaries, are comprised of the endothelium alone.) When the endothelium is intact and healthy, a clot, of course, should not form. A number of factors keep a clot from forming under these circumstances. Collagen, tissue factor and VWF remain out of contact the blood due to the intact endothelium. Prostacyclin (prostaglandin I2) is synthesized by the intact endothelium and prevents platelet activation. Nitric oxide is also released under these conditions, which keeps the blood vessels dilated TFPI (tissue factor pathway inhibitor, which is released from the endothelium, binds to tissue factor and keeps it inactive. Thrombomodulin binds thrombin and protein C, which activates protein C, which in turn inactives important clotting factors in the blood. heparan proteoglycan (heparin) binds and activates anti-thrombin, which in turn inactivates thrombin. Platelet Plug Starts to Form A break in the endothelium allows platelets to contact collagen and the other factors that activate platelets (see previous page). Platelets begin adhering to one ...
American Diagnostica TAT ELISA product no. 803 A presentation of American Diagnostica/Sekisui's ELISA for quantitative determination of Thrombin/Antithrombin III (TAT) complexes in human plasma samples. Transcript: In this presentation you will learn more about American Diagnostica/Sekisui's product No. 803 the so called TAT-Elisa. This is a quantitative enzyme-linked immunosorbent assay for the determination of Thrombin/Antithrombin III complexes in human plasma. The conversion of prothrombin to thrombin is a key event in thrombus formation. Thrombin is a serine protease that acts on various factors in the coagulation pathway and is a major player in thrombus formation. Antithrombin III (ATIII) is the major inhibitor of thrombin. Inactivation of thrombin by antithrombin III leads to the formation of a covalent inactive complex. Inactivation of thrombin, when being generated, proceeds immediately after formation so that the detection of the complex indicates ongoing thrombin formation. In other words: The "Thrombin-Antithrombin III" complex ("TAT"-complex) can be quantified in peripheral blood as an indicator of thrombin activation. Elevated plasma levels of TAT were found to be associated with a wide variety of active thrombotic events; in particular during disseminated intravascular coagulation, so called DIC; in cases of deep vein thrombosis (DVT); in sepsis and multiple trauma; during pregnancy complications, so called pre-eclampsia, and in a wide variety of malignancies. What are the ...
Hereditary antithrombin deficiency and rEVO Biologics' ATryn to appear on The Balancing Act™ Hereditary antithrombin (AT) deficiency featured on weekday morning show The Balancing Act on Lifetime Television. (Video: Business Wire)
Part 5 - Everything You Ever Wanted to Know About Clotting Venous Thromboembolism, Genetic Predisposition, Acquired Trigger(s), Thrombosis, family history of blood clotting, genetic thrombophilia, Factor V Leiden, Prothrombin Gene Mutation, Protein C deficiency, Protein S deficiency, Antithrombin-III deficiency, Dysfibrinogenemia,Autosomal dominant inheritance (Slides 16 - 20).
Normal Thrombus Formation Medical animation from High Impact
Hereditary Antithrombin Deficiency and rEVO Biologics' ATryn ... Hereditary antithrombin (AT) deficiency and the use of the rEVO Biologics' lead product ATryn Antithrombin (Recombinant) featured on weekday morning show The Balancing Act on Lifetime Television.
costco, cheap fish oil, omega 3, fish oil versus a quality omega 3 a customer tells how her husband used a cheap low quality fish oil, omega 3, for 4 years with no detectable benefit. He then switched to a high quality omega 3 and got rid of pain that had been there for 56 years, also got rid of IBS, irritable bowel that had been there for over 24 years.
Role of Estrogen Medical animation from High Impact
Grand Rounds - Current Perspectives on Antithrombin Deficiency
Going the Extra Mile to Ensure a Safe Delivery MaKeise-Faison-Ricks and her husband Donald discovered her blood deficiency after several losses while trying to conceive. Through a pioneering blood therapy and help from Shady Grove Adventist Hospital's Dr. Sheri Hamersley, an obstetrician specializing in maternal fetal medicine, and Dr. Michelle Spector, an obstetrician, MaKeise and Donald's wish for a family became a reality.
Production Of Therapeutic Glycoproteins : Competitor and Patent Landscape Report About the Report: The majority of clinically approved protein drugs bear some form of post-translational modification, most commonly glycosylation. Glycosylation is the attachment of a carbohydrate group to a protein, catalyzed by enzymes called glycosyl transferases. It is either N-linked, in which a carbohydrate is attached to the side chain of a specific asparagine, or O-linked, in which it is attached to the hydroxyl oxygen of a serine or threonine, the former being most prominent. While N-linked glycosylation occurs largely in the endoplasmic reticulum (ER) of mammalian cells, O-linked glycosylation initiates in either the ER or Golgi apparatus. Glycosylation is important because it can influence the therapeutic efficacy, immunogenicity, solubility, and in-vivo half life of the glycoprotein. A major obstacle in the pharmaceutical application of glycoproteins is the inherent heterogeneity of their glycan structures. Mammalian cell culture systems, especially Chinese hamster ovary (CHO) cells, are the preferred method for the production of therapeutic glycoproteins. Other systems such as E.coli, filamentous fungi, yeast, insects, plants and transgenic animals are also being engineered to produce proteins with optimal glycosylation pattern. Optimizing production methods to obtain a glycoform profile as similar to that in humans is the current goal in glycoengineering research. Some of the bestsellers among therapeutic proteins will soon lose patent protection. Therefore ...
HEMOCLOT Thrombin Inhibitors ACK002K.wmv
antithrombin morphing white
Michael Paidas, MD / What it means to discover: A researcher's perspective Michael Paidas, MD is an obstetrician gynecologist specializing in maternal-fetal medicine. His research is focused on the prevention, detection and management of pregnancy complications, including fetal loss, preeclampsia, fetal growth restriction, preterm delivery, abruption , and bleeding disorders. More on Michael Paidas's work: medicine.yale.edu.
Na+ dissociation from thrombin In collaboration with Enrico Di Cera, the Baker group bakergroup.wustl.edu studies the mechanism of cation-induced allosteric activation of thrombin, an important component of the blood coagulation cascade. This video shows a portion of a molecular dynamics simulation illustrating Na+ dissociation from its binding site on thrombin.
More Than You Ever Wanted To Know About Heparin Heparin is an anticoagulant. It also has many other important physiological functions. This film serves as an introduction to the molecular structure of heparin.
First Human Drug from Genetically Engineered Animals Approved FDA recently approved the first biological product made from genetically engineered animals. The product, called ATryn, is an anticoagulant used to prevent blood clots in patients with a rare disease known as hereditary antithrombin deficiency. These patients can develop blood clots during high-risk situations such as surgery and childbirth. The approval gives patients with this disease an important new treatment option. ATryn is a therapeutic protein made from the milk of genetically engineered goats. These goats have had a segment of DNA introduced into their genes that causes the female goats to produce human antithrombin in their milk. FDA's approval prohibits using these animals for food or feed, and also ensures that the genetic modification is not harming the animals. The manufacturer will continue to monitor the product's safety, including the possible development of immune responses in patients who receive repeated ATryn treatments. The product is expected to be available in the second quarter of 2009. FDA Patient Safety News: May 2009 For more information, please see our website: www.accessdata.fda.gov [vpdrugs]
Stroke Patient after treatment. You saw him in part 1, 2 adn 3. Now watch him in part 4. He suffered from a stroke that left him hemi-palegic. He is now able to walk on his own with a grocery cart.
TTC Update ~Doctor visit & Tests So my doctor has decided to test me for the following tests since I had a missed miscarriage in February 2011 and a recent very early miscarriage last cycle. Tests I had done: APO Protein A1 Anticardiolipin Ab Antithrombin III Assay Protein C activity Protein S antigen Homocysteine Factor V Leiden Prothrombin Gene Mutation CMP AIC Lupus Anticoagulant test I will be back in a few days with the results, what they mean and how they will be treated. Hopefully everything is just normal. Please pray for me. Baby dust to you all.
Vascular Dysfunction and Thrombin Generation In this video some background information on the concept of "vascular dsyfunction" and subsequent thrombin generation is presented. Selected evidence for the pathogenic importance of prothrombotic events in vascular dysfunction is also presented. Finally, American Diagnostica's products that assess biomarkers for hypercoagulabiity are presented: latex tests for D-Dimer, an ELISA for Thrombin and Antithrombin-complexes and the novel assay "Oligobind(TM) Thrombin assay", an enzyme-capture assay, which allows direct determination of thrombin activity in plasma samples.
ADI Product 840: APC-R clotting assay www.american- Product presentation ACTICLOT(R) Activated Protein C Resistance (no. 840) of American Diagnostica/Sekisui Hello, my name is Michael Kramer, I'm medical consultant to American Diagnostica. I want to present a few aspects of American Diagnostica's ACTICLOT Protein C Resistance Assay, Product No. 840, a clotting assay with high specificity and sensitivity for the determination of resistance to activated Protein C. Activated Protein C Resistance (APC-R) is the most frequent genetic defect associated with deep vein thrombosis. Heterozygous carriers have a 3-7 fold increased risk, homozygous carriers have a 80-100 fold increased risk. About 95% of the APC-R phenotype is caused by the Factor V Leiden mutation, abbreviated as FV:Q506. Here is a schematic description of the assay principle. The assay contains two snake venoms. 1st the venom RVV-V, a Factor V activating venom from Russel's viper and 2nd Noscarin, a Prothrombin activating venom from the Tiger snake. Noscarin activates Prothrombin to Thrombin, which then converts Fibrinogen to Fibrin and leads to the formation of a clot. Clotting is the ***ytical endpoint of the assay. The Noscarin mediated Prothrombin to Thrombin activation is accelerated by activated Factor Va, which is generated by the RVV-V venom. Activated Protein C is an inhibitor of Factor Va and once activated Protein C is present and Factor Va is susceptible to inhibition by activated Protein C, this leads to a reduced Noscarin ...
BIOL 2020 Hemostasis - Part 2 Brief discussion of the coagulation cascade, fibrinolytic system, and natural anticoagulants.
Michael Paidas, MD / Meet Yale Physicians: A Personal Perspective on Clinical Practice Michael J. Paidas, MD, is a maternal-fetal medicine (high-risk pregnancy) specialist. He directs the Program for Thrombosis and Hemostasis in Women's Health and the Women and Children's Center for Blood Disorders. He is an expert on preeclampsia, a complication of pregnancy linked to life-threatening cardiovascular disease. He received a peer-nominated Leffell Prize for Clinical Excellence, at Yale. More details on .
Physiologic Control of Hemostasis An explanation of physiologic mechanisms to control hemostasis including antithrombin III, protein C, protein S, and plasminogen.
Biophen Antithrombin 5 A221105 Information about Biophen Antithrombin 5 kit
Oligobind Thrombin Assay (product ADG844) This presentation describes the ADG product 844: Oligobind Thrombin ECA. This is an enzyme-capture assay (ECA) for the quantification of active thrombin in human samples, such as blood plasma. The detection of thrombin accurately reflects the current state of procoagulant activity. This is an advantage over indirect assays like the measurement of Thrombin-Antithrombin complexes, which rather reflect the average state of thrombin generation over a longer period of time. Taken together, Oligobind ECA may more accurately reflect the disease-relevant pro-coagulant phenotype and therefore represent a better basis for treatment decisions.